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Modern Science Meets Ancient Wisdom
We create products by leveraging the wisdom and principles from Ayurveda and Traditional Chinese Herbalism that have survived generations and marry them with the latest groundbreaking research to provide supplements that are rooted in tradition - and supported by science.
Our team has spent countless hours refining our formulations, ensuring that each product aligns with our commitment to safety, simplicity, and effectiveness. We believe in the power of natural solutions to unlock human potential, and our approach is rooted in the latest advancements in neuroscience and nutrition.
Nootropics are substances that enhance brain function, helping improve focus, memory, mental clarity, and cognitive performance. Often called “smart drugs” or “brain boosters,” they work by supporting neurotransmitter function, blood flow to the brain, and overall brain health.
At Noots, we use scientifically-backed all natural nootropics to help you achieve peak mental performance without crashes or jitters.
Adaptogens are natural substances, often derived from plants, that help your body adapt to stress and restore balance. They work by supporting your adrenal system, improving resilience to physical, mental, and emotional stressors. In Get Focused, adaptogens like Bacopa Monnieri and Kanna help promote calm focus, stress relief, and sustained energy.
Amino acids are the building blocks of proteins, essential for countless functions in the body, including brain health and energy production. Certain amino acids, like L-Tyrosine and L-Theanine, play a key role in neurotransmitter production, promoting mental clarity, focus, and relaxation. Our formula includes clinically-dosed amino acids to help you perform at your best.
Herbal extracts are concentrated compounds derived from plants, offering targeted health benefits. They’ve been used for centuries in traditional medicine and are now scientifically validated for their effectiveness. In Get Focused, herbal extracts like Lion’s Mane and Panax Ginseng provide natural solutions for enhanced memory, focus, and energy.


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L-Tyrosine
The Focus and Stress-Resilience Amino Acid
L-Tyrosine is an amino acid known to aid in the production of neurotransmitters like dopamine and norepinephrine, which are crucial for cognitive functions such as memory, focus, and mood regulation. It may help alleviate the effects of stress and fatigue, potentially improving mental performance, particularly in stressful situations or when multitasking.
Additionally, L-Tyrosine can support the synthesis of thyroid hormones, which are vital for regulating metabolism and overall energy levels.
Overview of L-Tyrosine
L-Tyrosine is a non-essential amino acid that plays a crucial role in the synthesis of several important neurotransmitters, including dopamine, norepinephrine, and epinephrine. It is synthesized in the body from phenylalanine, an essential amino acid obtained through diet. L-Tyrosine is classified as a conditionally essential amino acid, meaning that while the body can produce it, supplementation may be beneficial under certain conditions, particularly during stress or cognitive challenges.
Mechanism of Action
L-Tyrosine functions primarily as a precursor for catecholamines, which are neurotransmitters that play key roles in mood regulation, stress response, and cognitive function. Here’s how it works:
1. Synthesis of Catecholamines:
- L-Tyrosine is converted into L-DOPA by the enzyme tyrosine hydroxylase (TH), which is the rate-limiting step in dopamine synthesis.
- L-DOPA is then further converted into dopamine. Dopamine can subsequently be transformed into norepinephrine and epinephrine through additional enzymatic reactions[1][4].
2. Response to Stress:
- During stressful situations, the body’s demand for catecholamines increases. Supplementation with L-Tyrosine can help replenish these neurotransmitters when they become depleted. This is particularly relevant during periods of acute stress or cognitive overload[2][5].
- Research indicates that L-Tyrosine can enhance cognitive performance and improve mental flexibility under stress by boosting the synthesis of these neurotransmitters in actively firing neurons[1][4].
3. Absorption and Bioavailability:
- After oral supplementation, L-Tyrosine levels peak in the bloodstream within 1 to 2 hours and can remain elevated for up to 8 hours. It crosses the blood-brain barrier and is actively transported into brain cells where it undergoes conversion to catecholamines[1][3].
4. Effects on Mood and Cognition:
- Elevated levels of norepinephrine and dopamine are associated with improved mood and cognitive function. Studies have shown that L-Tyrosine administration can enhance working memory, response inhibition, and task-switching abilities, especially in challenging conditions[4][5].
Conclusion
L-Tyrosine serves as a vital precursor for neurotransmitter synthesis, particularly during stressful situations where cognitive demands are high. Its ability to enhance catecholamine production can lead to improved mental performance and mood stabilization, making it a valuable supplement for individuals facing acute stressors or cognitive challenges.
Citations:
[1] https://examine.com/supplements/l-tyrosine/
[2] https://go.drugbank.com/drugs/DB00135
[3] https://en.wikipedia.org/wiki/Tyrosine
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC6084775/
[5] https://www.mountsinai.org/health-library/supplement/tyrosine
L-Tyrosine offers several potential benefits, particularly in relation to cognitive function and stress management.
Here’s a summary of its key advantages:
Cognitive Performance Under Stress: L-Tyrosine has been shown to help maintain cognitive function during stressful situations. It can alleviate declines in working memory and information processing that occur when the brain is under acute stress, such as during military training or extreme environmental conditions[1][4][10].
Enhancement of Neurotransmitter Levels: As a precursor to catecholamines like dopamine and norepinephrine, L-Tyrosine supports the synthesis of these neurotransmitters, which can become depleted during stress. This replenishment may improve mood and cognitive performance[2][3][10].
Improved Task Performance: Studies indicate that L-Tyrosine supplementation can enhance cognitive flexibility and multitasking abilities, particularly in demanding situations. This includes better performance on tasks requiring attention and quick switching between different cognitive demands[4][9].
Support for Mental Resilience: By boosting levels of catecholamines, L-Tyrosine may help individuals cope with stress more effectively, reducing feelings of fatigue and improving overall mental resilience[3][10].
Potential Benefits for Mood Disorders: There is some evidence suggesting that L-Tyrosine may help alleviate symptoms of depression by addressing neurotransmitter imbalances related to mood regulation, although more research is needed in this area[4][9].
Physical Performance: While the evidence is mixed regarding athletic performance, some studies suggest that L-Tyrosine may help maintain performance levels during prolonged physical exertion by supporting mental focus and reducing perceived exertion[9][10].
Thyroid Function Support: L-Tyrosine is involved in the production of thyroid hormones, which are essential for regulating metabolism and energy levels in the body[4].
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC1863555/
[2] https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2014.01101/full
[3] https://www.ncbi.nlm.nih.gov/books/NBK209061/
[4] https://health.clevelandclinic.org/l-tyrosine
[5] https://pure.rug.nl/ws/portalfiles/portal/133942762/1_s2.0_S0091305715000945_main.pdf
[6] https://www.tandfonline.com/doi/full/10.1080/10253890.2024.2375588
[7] https://www.webmd.com/vitamins/ai/ingredientmono-1037/tyrosine
[8] https://pubmed.ncbi.nlm.nih.gov/25797188/
Cognitive Control and Individual Differences: A study found that L-Tyrosine can enhance cognitive control in healthy individuals, particularly under stress, by replenishing dopamine levels, which are often depleted during demanding tasks [1].
Mitigation of Cognitive Decline During Stress: Research indicated that L-Tyrosine supplementation effectively prevents declines in cognitive function due to physical stressors, such as cold exposure and sleep deprivation, improving various cognitive tasks [2].
Short-term Cognitive Enhancement: A review highlighted that L-Tyrosine supplementation is beneficial for enhancing cognitive performance in stressful situations, though its effectiveness varies depending on the individual's baseline neurotransmitter function [3].
Stress Reduction and Cognitive Processes: Another study confirmed that L-Tyrosine helps mitigate the negative impacts of stressors like sleep deprivation and extreme climates on cognitive processes, including memory and reasoning [4].
Cognitive Performance Under Stress: A systematic review concluded that while L-Tyrosine may not significantly enhance physical performance under stress, it consistently shows positive effects on cognitive performance in stressful conditions [5].
Physiological Effects and Cognitive Tasks: Research demonstrated that L-Tyrosine intake reduced autonomic arousal and improved response times in cognitive tasks without compromising performance, suggesting its potential to enhance goal-directed control during decision-making [7].
Safety and Tolerance: A comprehensive analysis indicated that L-Tyrosine is safe and well-tolerated at moderate doses, effectively preventing cognitive decline under stress while showing mixed results regarding memory enhancement in non-stressful conditions [8].
Citations:
[1] https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2014.01101/full
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC1863555/
[3] https://pubmed.ncbi.nlm.nih.gov/26424423/
[4] https://www.gowinglife.com/l-tyrosine-may-improve-your-cognitive-performance-under-stress/
[6] https://www.tandfonline.com/doi/full/10.1080/10253890.2024.2375588
[7] https://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1010785
Bacopa Monnieri (Synapsa®)
The Memory-Enhancing Herb
Bacopa monnieri is an adaptogenic plant that has been used in traditional Indian cultures for many centuries. It may improve learning ability, enhance memory processing, and improve mental performance.
Synapsa® is a patented form of Bacopa that is patented and has been the subject of more than 35 years of clinical study. It's made from a Whole Plant Extract standardized to 55% Bacosides to ensure a potent and consistent concentration of the active compounds responsible for its cognitive benefits. This high standardization enhances memory, focus, and mental performance, providing maximum efficacy backed by clinical research.†
Bacopa Monnieri, particularly in its standardized extract form known as Synapsa®, is recognized for its cognitive-enhancing properties. Here’s how it works:
Mechanisms of Action
1. Neurotransmitter Modulation: Bacopa Monnieri contains active compounds called bacosides, particularly bacosides A and B, which are known to cross the blood-brain barrier. These compounds modulate neurotransmitter levels, including:
- Acetylcholine: By activating choline acetyltransferase (an enzyme involved in acetylcholine production) and inhibiting acetylcholinesterase (the enzyme that breaks down acetylcholine), Bacopa increases acetylcholine levels, enhancing memory and learning abilities [1][2].
- Dopamine: Bacopa helps preserve dopamine synthesis, which is crucial for motivation and mood regulation. It protects dopaminergic neurons from degeneration, particularly important as dopamine levels decline with age [2][3].
- Serotonin: The extract also increases serotonin levels in the brain, contributing to improved mood and cognitive function [3].
2. Antioxidant Effects: Bacopa exhibits significant antioxidant properties, protecting neurons from oxidative stress. This neuroprotection is essential for maintaining cognitive health and preventing neurodegenerative diseases [1][6].
3. Anti-inflammatory Properties: Bacopa has anti-inflammatory effects that can help reduce neuroinflammation, which is linked to cognitive decline and various neurological disorders. It modulates the activity of microglial cells, which play a role in brain inflammation [1][5].
4. Promotion of Neuronal Communication: Bacopa enhances synaptic communication by promoting the growth of dendrites (nerve endings), thereby improving the brain's ability to communicate effectively [4][5].
5. Cerebral Blood Flow Enhancement: The extract may increase cerebral blood flow, ensuring that the brain receives adequate oxygen and nutrients necessary for optimal function [6].
In summary, Bacopa Monnieri (Synapsa®) works through a combination of neurotransmitter modulation, antioxidant and anti-inflammatory effects, promotion of neuronal growth, and enhancement of cerebral blood flow, all contributing to its cognitive-enhancing capabilities.
Citations:
[1] https://www.ncbi.nlm.nih.gov/books/NBK589635/
[3] https://examine.com/supplements/bacopa-monnieri/research/
[4] https://nootropicsdepot.com/synapsa-bacopa-monnieri-extract-whole-plant-320mg-capsules/
[5] https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.972379/full
[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC3746283/
[7] https://www.mdpi.com/1420-3049/24/12/2243
[8] https://onlinelibrary.wiley.com/doi/toc/10.1155/4747.si.342354
Bacopa Monnieri, particularly in its standardized extract form known as Synapsa®, offers a range of cognitive and health benefits. Here’s a summary of its key advantages:
Enhanced Memory and Learning: Synapsa® has been shown to improve memory retention and learning rates, with studies indicating significant improvements in delayed recall tasks and reduced rates of forgetting new information over time [1][5].
Cognitive Performance Improvement: Research demonstrates that Bacopa Monnieri can enhance cognitive performance, particularly in tasks requiring attention and information processing, making it beneficial for multitasking and complex cognitive activities [1][5][6].
Stress Reduction: Bacopa acts as an adaptogen, helping to reduce stress responses by modulating the hypothalamic-pituitary-adrenal (HPA) axis output, which can lead to improved emotional well-being and reduced anxiety levels [5][7].
Antioxidant Properties: The active compounds in Bacopa, particularly bacosides, exhibit strong antioxidant effects that protect brain cells from oxidative stress, potentially reducing the risk of neurodegenerative diseases [1][7].
Neuroprotective Effects: Bacopa Monnieri may promote neuronal health by enhancing synaptic communication and supporting the growth of dendrites, which are essential for effective brain function [5][6].
Mood Enhancement: By increasing serotonin levels and modulating neurotransmitter activity, Bacopa can contribute to improved mood and overall mental health [1][5].
Potential ADHD Support: Some studies suggest that Bacopa may help alleviate symptoms associated with attention deficit hyperactivity disorder (ADHD), improving focus and concentration in affected individuals [7][8].
Anti-inflammatory Effects: Bacopa has been shown to reduce inflammation by inhibiting pro-inflammatory cytokines, which may have implications for overall brain health and chronic disease prevention [7][8].
In summary, Bacopa Monnieri (Synapsa®) is a powerful nootropic that supports cognitive function, enhances memory, reduces stress, and provides neuroprotective benefits through its unique active compounds.
Citations:
[1] https://www.ncbi.nlm.nih.gov/books/NBK589635/
[2] https://www.nature.com/articles/1395862
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC3153866/
[4] https://pubmed.ncbi.nlm.nih.gov/24252493/
[5] https://nootropicsdepot.com/synapsa-bacopa-monnieri-extract-whole-plant-320mg-capsules/
[6] https://www.plthealth.com/product-catalog/synapsa
[7] https://www.healthline.com/nutrition/bacopa-monnieri-benefits
[8] https://www.verywellhealth.com/the-benefits-of-bacopa-89039
Here are several peer-reviewed human research studies on Bacopa Monnieri (Synapsa®) along with key takeaways from each:
Cognitive Training and Bacopa Monnieri:
A study involving 28 healthy adults aged 57-78 years found that those taking Bacopa Monnieri showed improved accuracy in cognitive tasks, indicating that it may enhance cognitive function by increasing neuronal connections, despite a trade-off with reaction speed. This suggests potential benefits for cognitive health in aging populations [1].
Cognitive Enhancement and Neuroprotection: A systematic review highlighted that Bacopa Monnieri has the potential to improve cognitive performance, particularly in attention speed, although the effects can be inconsistent across different tests and populations. This indicates that while Bacopa may enhance cognition, results may vary depending on individual circumstances [4].
Emotional Function in Parkinson's Disease:
A pilot trial suggested that Bacopa Monnieri might improve emotional function in individuals with Parkinson's disease, pointing to its potential neuroprotective effects and benefits for mood regulation in neurodegenerative conditions [4].
Neuropharmacological Review:
A comprehensive review reported that Bacopa Monnieri could provide neuroprotection and cognitive enhancement through various mechanisms, including antioxidant activity and modulation of neurotransmitter systems, supporting its use as a nootropic agent [3].
Effects on Memory Recognition:
Research demonstrated that Bacopa Monnieri treatment led to partial restoration of cognitive deficits and increased GABAergic neuronal density in a model of schizophrenia, suggesting its potential for enhancing memory recognition and providing neuroprotective effects [5].
These studies collectively support the cognitive-enhancing properties of Bacopa Monnieri (Synapsa®), particularly regarding memory, attention, and emotional regulation, while also indicating variability in effectiveness across different populations and contexts.
Citations:
[2] https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.972379/full
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC3746283/
Alpha-GPC
The Cognitive Performance Nutrient
Alpha-GPC or Alpha Glycerylphosphorylcholine is found in a variety of every day foods (like eggs). It is known for its cognitive boosting properties and to enhance power output in athletes. It supports cellular membranes and aids in helping brains stay sharp.†
Alpha-GPC (alpha-glycerophosphocholine) is a choline-containing compound that plays a significant role in cognitive function and physical performance. Here's how it works:
Mechanisms of Action
Increased Acetylcholine Levels: Alpha-GPC is rapidly absorbed and crosses the blood-brain barrier, where it is metabolized into choline. This choline serves as a precursor for acetylcholine, a neurotransmitter essential for memory, attention, and muscle contraction. By increasing the synthesis and release of acetylcholine, Alpha-GPC enhances cognitive functions such as learning and memory, as well as physical performance through improved muscle activation [1][2].
Support for Cellular Membranes: Besides its role in acetylcholine synthesis, Alpha-GPC contributes to the formation of phosphatidylcholine, a crucial component of cell membranes. This supports overall brain health and cellular function [2].
Dopaminergic and Serotonergic Modulation: Research suggests that Alpha-GPC may also influence dopaminergic and serotonergic systems, potentially enhancing motivation and emotional well-being by increasing dopamine and serotonin levels in the brain [3].
Neuroprotective Effects: Alpha-GPC has been shown to have neuroprotective properties, which may help mitigate cognitive decline associated with aging or neurodegenerative diseases by promoting neuronal health and function [3][4].
Physical Performance Enhancement: Studies indicate that Alpha-GPC supplementation can improve physical performance metrics such as strength and endurance by preventing exercise-induced reductions in choline levels and enhancing muscle contraction efficiency [2].
In summary, Alpha-GPC works primarily by increasing acetylcholine levels in the brain, supporting cognitive function and physical performance, while also contributing to cellular health and exhibiting neuroprotective effects.
Citations:
[1] https://examine.com/supplements/alpha-gpc/
Alpha-GPC (alpha-glycerophosphocholine) offers several benefits, particularly related to cognitive function and physical performance. Here’s a summary of its key advantages:
Enhanced Memory and Learning: Alpha-GPC is known to improve memory and learning by increasing acetylcholine levels in the brain, which is crucial for cognitive processes. Studies suggest it can benefit individuals with cognitive impairments, such as those suffering from Alzheimer's disease and dementia [1][8].
Improved Focus and Attention: Supplementation with Alpha-GPC has been shown to enhance focus and attention in healthy individuals, making it beneficial for tasks that require sustained mental effort [2][4].
Increased Motivation: Research indicates that Alpha-GPC can boost motivation levels, particularly in healthy adults, which may enhance overall productivity and engagement in various activities [2][8].
Physical Performance Enhancement: Alpha-GPC supplementation has been linked to improvements in physical performance, particularly in strength and power output during exercises. It helps increase lower body force production and enhances explosive performance metrics [3][7].
Support for Recovery: The compound may facilitate faster recovery post-exercise by improving heart rate variability and blood pressure regulation, aiding athletes in maintaining their training regimens [3][5].
Neuroprotective Effects: Alpha-GPC exhibits neuroprotective properties that may help mitigate cognitive decline associated with aging, supporting overall brain health [1][6].
Boosted Growth Hormone Production: Supplementation with Alpha-GPC has been shown to stimulate growth hormone secretion, which is important for muscle growth and recovery, benefiting athletes aiming for improved physical conditioning [3][5].
Cognitive Health Maintenance: Regular intake of Alpha-GPC may support long-term cognitive health by ensuring adequate levels of acetylcholine, which is essential for maintaining various cognitive functions as one ages [6][9].
In summary, Alpha-GPC is a versatile supplement that enhances cognitive function, boosts physical performance, supports recovery, and promotes overall brain health through its action on acetylcholine levels and other neurochemical pathways.
Citations:
[1] https://draxe.com/nutrition/alpha-gpc/
[3] https://gethellobatch.com/blogs/insights/alpha-gpc-supplements
[4] https://www.vitarx.co/resources/brain-memory-focus/can-alpha-gpc-boost-your-cognitive-performance
[5] https://grapplescience.com/blogs/journal/the-benefits-of-alpha-gpc
[6] https://www.lifeextension.com/wellness/supplements/alpha-gpc-benefits
[7] https://pubmed.ncbi.nlm.nih.gov/26582972/
Here are several peer-reviewed human research studies on Alpha-GPC related to focus and performance, along with key takeaways from each:
Acute Alpha-GPC Supplementation and Cognitive Performance:
A study found that both high-dose (630 mg) and low-dose (315 mg) Alpha-GPC supplementation significantly increased cognitive performance in young, healthy males, as measured by improvements in the Stroop Total Score and completion time of cognitive tasks, indicating its effectiveness in enhancing focus and mental clarity [2].
Motivation and Mental Performance:
Research indicated that Alpha-GPC treatment significantly increased motivation levels in healthy individuals, particularly in the evening, suggesting its potential to enhance mental focus and emotional well-being without affecting anxiety levels [7].
Cognitive Function Enhancement:
A systematic review highlighted that Alpha-GPC supplementation improved cognitive performance metrics such as reaction times during tasks, supporting its role as a cognitive enhancer for both clinical populations and healthy individuals [3].
Physical Performance and Cognitive Effects:
A study demonstrated that Alpha-GPC supplementation improved lower body force production during resistance training while also enhancing cognitive performance metrics, suggesting a dual benefit for physical and mental performance [5].
Cognitive Benefits in Healthy Volunteers:
Another study showed that daily Alpha-GPC supplementation improved cognitive function and motivation in healthy volunteers, reinforcing its potential as a nootropic agent for enhancing focus and performance [4].
These studies collectively support the cognitive-enhancing effects of Alpha-GPC, particularly regarding focus, motivation, and overall mental performance, making it a valuable supplement for individuals seeking to improve their cognitive abilities.
Citations:
[1] https://www.vitarx.co/resources/brain-memory-focus/can-alpha-gpc-boost-your-cognitive-performance
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC11644786/
[3] https://www.mdpi.com/2072-6643/16/23/4240
[4] https://pubmed.ncbi.nlm.nih.gov/39683633/?fc=None&ff=20241221161636&v=2.18.0.post9+e462414
[6] https://www.tandfonline.com/doi/full/10.1186/s12970-017-0196-5
Lion’s Mane Extract
The Brain-Boosting Mushroom
Lion’s Mane is a mushroom that's been used as a tea for thousands of years by Buddhist monks. Today, it's known for its powerful effects as a “brain tonic" because of it's ability to increase brain power, heighten people's ability to focus, and improve memory and cognition.
At Noots, we use a 10:1 extract of Lion’s Mane for superior potency. This means that every 1mg of Lion’s Mane extract in our formula is equivalent to 10mg of the raw mushroom, delivering maximum effectiveness in every serving.†
Lion's Mane Extract, derived from the mushroom Hericium erinaceus, has gained attention for its potential neuroprotective and cognitive-enhancing effects. Here’s how it works:
Mechanisms of Action
Nerve Growth Factor (NGF) Stimulation: Lion's Mane Extract contains bioactive compounds known as hericenones and erinacines, which have been shown to stimulate the synthesis of Nerve Growth Factor (NGF). NGF is crucial for the growth, maintenance, and survival of neurons. This stimulation supports neuronal health and may enhance cognitive functions such as memory and learning [1][2].
Neuroprotection:
The extract exhibits neuroprotective properties by promoting neuronal growth and myelination. Studies have indicated that it can enhance the growth of neurite extensions in cultured brain cells, suggesting its potential to protect against neurodegenerative conditions [1][4].
Crossing the Blood-Brain Barrier:
Compounds such as erinacines have been found to cross the blood-brain barrier, allowing them to exert their effects directly on brain cells. This ability enhances their potential therapeutic applications for cognitive disorders [2].
Antioxidant Effects:
Lion's Mane Extract possesses antioxidant properties that help reduce oxidative stress in the brain. By combating oxidative damage, it may contribute to overall brain health and lower the risk of cognitive decline associated with aging [3].
Modulation of Neurotransmitters:
Some studies suggest that Lion's Mane may influence monoamine neurotransmitters, potentially improving mood and cognitive function through enhanced serotonergic and dopaminergic activity [5].
Summary
In summary, Lion's Mane Extract works primarily through its ability to stimulate NGF production, promote neuronal growth and myelination, provide neuroprotection, reduce oxidative stress, and modulate neurotransmitter activity. These mechanisms contribute to its potential benefits for cognitive enhancement and overall brain health.
Citations:
[1] https://restorativemedicine.org/library/monographs/lions-mane/
[2] https://www.ncbi.nlm.nih.gov/books/NBK599740/
[3] https://www.healthline.com/nutrition/lions-mane-mushroom
[4] https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
Lion's Mane Mushroom (*Hericium erinaceus*) offers a variety of health benefits, particularly related to cognitive function, mental health, and overall well-being. Here’s a summary of its key advantages based on recent research:
Cognitive Health: Lion's Mane has been shown to improve cognitive function, enhance memory, and support nerve recovery by promoting the expression of neurotrophic factors crucial for nerve cell growth and maintenance. This makes it potentially beneficial for conditions like Alzheimer's and Parkinson's disease [1].
Mental Health Improvement: The mushroom may help reduce symptoms of depression and anxiety by promoting neurogenesis and increasing serotonin production, which is associated with mood regulation [1][7].
Antioxidant and Anti-Inflammatory Properties: Lion's Mane exhibits strong antioxidant and anti-inflammatory effects that help protect against oxidative stress and inflammation, potentially reducing the risk of chronic diseases [1][3].
Immune System Support: It enhances the immune system's response by stimulating the production of various immune cells and cytokines, making it effective in fighting infections and supporting overall immune health [1][3].
Potential Anticancer Effects: Research has identified compounds in Lion's Mane that may inhibit the proliferation of cancer cells and induce apoptosis in various cancer cell lines, suggesting potential anticancer properties [1].
Cardiovascular Health: Lion's Mane may benefit cardiovascular health by reducing blood lipid levels and improving heart function, which helps maintain healthy blood pressure and cholesterol levels [1].
Neuroprotection: The extract has been found to protect neurons from damage, enhancing neuronal growth and myelination, which is vital for maintaining cognitive function as one ages [7][6].
Enhanced Memory Recognition: Studies indicate that Lion's Mane can improve memory recognition in animal models, suggesting it may have similar effects in humans [4][7].
Stress Reduction: Preliminary studies suggest that Lion's Mane may help reduce subjective stress levels, contributing to improved overall mental well-being [8].
In summary, Lion's Mane Mushroom is a versatile natural resource with a wide range of health benefits, particularly for cognitive enhancement, mental health support, immune function, and overall well-being. As research continues to explore its potential, it remains a valuable addition to a healthy diet and lifestyle.
Citations:
[1] https://consensus.app/home/blog/health-benefits-of-lions-mane-mushrooms/
[3] https://www.medicalnewstoday.com/articles/323400
[5] https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms
[6] https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
[7] https://www.healthline.com/nutrition/lions-mane-mushroom
Here are a few peer-reviewed human research studies on Lion's Mane extract (Hericium erinaceus) related to focus and performance, along with key takeaways from each:
Acute Cognitive Benefits Study: A double-blind, randomized, placebo-controlled crossover study found that a single dose of 1 g of Lion's Mane extract significantly improved working memory, attention, and reaction time in healthy adults within 1-2 hours post-ingestion, suggesting its potential for enhancing cognitive performance rapidly [1].
Chronic Supplementation Effects:
In a 12-week randomized, double-blind, placebo-controlled study, participants who consumed Lion's Mane extract showed significant improvements in cognitive functions as measured by the Mini Mental State Examination (MMSE), indicating its potential role in preventing cognitive decline [2][6].
Pilot Study on Acute and Chronic Effects:
A pilot study demonstrated that acute ingestion of 1.8 g of Lion's Mane resulted in quicker performance on cognitive tasks such as the Stroop task at 60 minutes post-dose, while chronic supplementation over 28 days led to trends toward reduced subjective stress and improved cognitive performance in young adults [3][4].
Cognitive Performance and Mood Enhancement:
Research indicated that participants taking Lion's Mane extract exhibited improved working memory and complex attention, along with enhanced perceptions of happiness over a two-hour period following ingestion, highlighting its immediate cognitive benefits [5].
Neuroprotective Effects:
A study suggested that the bioactive compounds in Lion's Mane, particularly hericenones and erinacines, may promote nerve growth factor synthesis and have neuroprotective effects, supporting overall brain health and cognitive function [3][4].
These studies collectively suggest that Lion's Mane extract may enhance focus, working memory, attention, and overall cognitive performance while also potentially reducing stress and supporting brain health.
Citations:
[2] https://pubmed.ncbi.nlm.nih.gov/31413233/
Guarana
The Natural Caffeine Powerhouse
Guarana is a natural plant extract known for its high caffeine content, making it a powerful and long-lasting energy source. Often used to boost physical strength, endurance, and mental alertness, it’s classified as a nootropic for its ability to enhance focus and cognitive performance. At
Noots, we’ve chosen guarana as a sustainable and effective alternative to traditional caffeine sources, ensuring you get the energy and mental clarity you need without compromise.†
Guarana, derived from the seeds of the Paullinia cupana plant, is known for its stimulant properties primarily due to its caffeine content. Here’s how it works:
Mechanisms of Action
Caffeine Content: Guarana contains between 2.5% to 5% caffeine by weight, which is a central nervous system stimulant. Caffeine acts as an antagonist of adenosine receptors, leading to increased alertness, reduced fatigue, and enhanced cognitive performance by promoting the release of neurotransmitters like dopamine and norepinephrine [4][5].
Enhanced Stimulation: Research indicates that guarana provides additional stimulation beyond that of caffeine alone. Studies have shown that guarana can enhance locomotor activity in model organisms, suggesting it may offer a synergistic effect when combined with other stimulants like caffeine and glucose [1].
Neuroprotective Effects: Guarana has demonstrated antioxidant properties, which help protect neurons from oxidative stress. This action is attributed to its ability to scavenge free radicals and inhibit lipid peroxidation, potentially contributing to improved cognitive health [2][6].
Mood and Cognitive Performance: Guarana has been associated with improvements in mood and cognitive performance. Some studies suggest that it can enhance response times in cognitive tasks while also positively affecting mood and affective states [3].
Anxiolytic Properties: Chronic exposure to guarana has been linked to anxiolytic effects, which may involve modulation of dopaminergic and serotonergic neurotransmission systems, further supporting its role in mood enhancement [2].
In summary, guarana works primarily through its caffeine content, which stimulates the central nervous system, enhances cognitive function, provides antioxidant benefits, and potentially improves mood and anxiety levels. Its unique properties make it a popular ingredient in energy drinks and dietary supplements aimed at boosting mental performance and reducing fatigue.
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC4399916/
[2] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/guarana
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC9865053/
[4] https://www.medicinenet.com/guarana_paullinia_cupana-oral/article.htm
[5] https://reference.medscape.com/drug/brazilian-cocoa-guarana-gum-guarana-344539
Here are several peer-reviewed human research studies on guarana related to performance and focus, along with key takeaways from each:
Guarana and Cognitive Performance:
A systematic review indicated that guarana supplementation improved reaction time and accuracy in cognitive tasks, although no significant differences were found when compared to caffeine, suggesting it can enhance cognitive performance but may not outperform traditional stimulants like caffeine [1].
Acute Effects of Guarana on Response Time: A meta-analysis revealed that acute ingestion of guarana led to a small but significant improvement in response time during various cognitive tasks without affecting accuracy, highlighting its potential to enhance mental performance [2].
Cognitive Effects Post-Exercise:
Research demonstrated that guarana supplementation decreased simple reaction time (SRT) and choice reaction time (CRT) after maximal intensity cycling, indicating its effectiveness in maintaining cognitive performance even following physical exertion [5].
Guarana's Protective Effects Against Cognitive Fatigue: A study found that guarana improved cognitive performance metrics such as alertness and speed of attention after exercise, suggesting it may help mitigate cognitive fatigue and maintain focus during demanding tasks [5].
5. Overall Cognitive Task Performance: A systematic review concluded that while guarana had a positive effect on response times across various cognitive tasks, the overall effects on cognitive performance were not significant when compared to placebo, indicating variability in its effectiveness [4].
These studies collectively suggest that guarana can enhance cognitive performance, particularly in terms of reaction time and focus, although its effects may not always surpass those of caffeine or be consistent across different contexts.
Citations:
[1] https://sciendo.com/article/10.2478/gp-2019-0015
[2] https://pubmed.ncbi.nlm.nih.gov/36678305/
[3] https://intapi.sciendo.com/pdf/10.2478/gp-2019-0015
Guarana, derived from the seeds of the Paullinia cupana plant, offers a variety of health benefits, primarily due to its high caffeine content and other bioactive compounds. Here’s a list of its key benefits:
Increased Energy Levels: Guarana is well-known for its stimulant effects, primarily due to its caffeine content, which can help reduce fatigue and enhance overall energy levels [1][4].
Enhanced Cognitive Function: Research indicates that guarana can improve cognitive performance by increasing reaction times and accuracy in cognitive tasks, making it beneficial for focus and mental clarity [2][5].
Antioxidant Properties: Guarana is rich in antioxidants, which help neutralize free radicals and reduce oxidative stress, potentially lowering the risk of chronic diseases [1][6].
Weight Loss Support: Guarana may aid in weight loss by acting as an appetite suppressant and boosting metabolism, although more research is needed to confirm its effectiveness in this area [1][4].
Improved Mood and Mental Alertness: The caffeine in guarana can enhance mood and increase alertness, contributing to better overall mental health [5][7].
Pain Relief: Guarana's caffeine content may provide pain-relieving effects by blocking adenosine receptors, which are involved in pain perception [1][4].
Heart Health Benefits: Some studies suggest that guarana may improve cardiovascular health by enhancing blood flow and reducing LDL cholesterol oxidation [1][10].
Antimicrobial Effects: Guarana has been shown to possess antimicrobial properties, making it beneficial for skin health and as an ingredient in cosmetic products [1][3].
Potential Anti-Cancer Properties: Preliminary research indicates that guarana may have anticancer effects due to its antioxidant properties and ability to reduce oxidative stress [9][10].
Support for Eye Health: Guarana may help reduce the risk of age-related eye diseases due to its antioxidant content [1][10].
In summary, guarana is a versatile ingredient that provides various health benefits, particularly related to energy enhancement, cognitive function, and antioxidant protection.
Citations:
[1] https://www.healthline.com/nutrition/guarana-benefits
[2] https://sciendo.com/article/10.2478/gp-2019-0015
[3] https://dergipark.org.tr/en/download/article-file/1081291
[4] https://www.webmd.com/diet/supplement-guide-guarana
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9865053/
[7] https://health.clevelandclinic.org/guarana
[9] https://pubmed.ncbi.nlm.nih.gov/34755935/
[10] https://www.medicalnewstoday.com/articles/guarana-benefits
Methylliberine (Dynamine®)
The Energy and Motivation Enhancer
Methylliberine is a naturally occurring compound found in the kucha leaf. Known for its ability to enhance energy, focus, and mood, it works synergistically with caffeine to amplify and extend its benefits without overstimulation. Unlike caffeine, Methylliberine provides clean, long-lasting energy, making it a popular nootropic for boosting mental clarity and motivation without the crash.
Dynamine® is a patented form of Methylliberine with clinical studies.†
Dynamine (methylliberine) is a purine alkaloid that affects energy, focus, and cognitive performance through several mechanisms. Here’s how it works, supported by peer-reviewed research:
Mechanisms of Action
Adenosine Receptor Modulation:
Dynamine acts as an allosteric modulator of adenosine receptors, specifically decreasing their sensitivity rather than directly blocking them like caffeine. This modulation helps to reduce fatigue signals in the brain, promoting alertness and energy levels without the tolerance buildup associated with caffeine [1][5].
Dopamine Reuptake Inhibition:
It functions as a reuptake inhibitor for dopamine, increasing dopamine levels in the brain. This enhancement plays a crucial role in mood regulation, motivation, and cognitive performance, as dopamine is linked to pleasure and learning [3][5].
Neurophysiological Effects:
Studies have shown that Dynamine can increase delta and theta brain wave activity, which are associated with cognitive control and attentional processes. This suggests that Dynamine may enhance focus and mental clarity during tasks that require sustained attention [2][8].
Synergistic Effects with Caffeine:
When combined with caffeine and TeaCrine, Dynamine has been found to improve cognitive performance in gaming scenarios by enhancing reaction times while maintaining precision and accuracy. This combination helps mitigate the negative effects of caffeine alone, such as increased anxiety and decreased performance accuracy [4][8].
Short Half-Life:
Dynamine has a relatively short half-life of about 1.5 hours compared to caffeine's longer duration (5-7 hours). This allows for quick onset of effects without prolonged stimulation, making it ideal for acute cognitive enhancement [3][6].
In summary, Dynamine works primarily through adenosine receptor modulation and dopamine reuptake inhibition, leading to increased energy, improved focus, enhanced mood, and better cognitive performance. Its synergistic effects with other compounds like caffeine further enhance its benefits without significant adverse effects on heart rate or blood pressure [1][4].
Citations:
[1] https://www.theoptimizingblog.com/dynamine/
[2] https://compoundsolutions.com/the-science-behind-energy-mood-motivation-focus/
[3] https://swolverine.com/blogs/blog/what-is-dynamine
[4] https://pubmed.ncbi.nlm.nih.gov/35103121/
[5] https://primevallabs.com/blogs/news/dynamine-the-full-breakdown
[6] https://www.memphis.edu/nutraceutical/pdfs/12-2020-mra-methylliberine-safety.pdf
Here are the benefits of Dynamine (methylliberine) supported by peer-reviewed research:
Increased Energy Levels: Dynamine provides a rapid boost in energy without the jitteriness or crash commonly associated with caffeine, making it an effective alternative for enhancing physical performance and reducing fatigue during workouts [1][7].
Improved Focus and Concentration: Research indicates that Dynamine enhances mental alertness and concentration, allowing individuals to maintain better focus on tasks, whether in physical activities or cognitive challenges [2][9].
Enhanced Mood and Motivation: Studies show that Dynamine supplementation leads to significant improvements in mood and motivation, contributing to a more positive mental state and greater willingness to engage in tasks [2][5][9].
Sustained Effects: Unlike caffeine, which can lead to tolerance, Dynamine has been shown to provide sustained energy and focus without diminishing returns over time, allowing for consistent performance enhancement [1][7].
Synergistic Effects with Other Stimulants: When combined with caffeine and other compounds like TeaCrine, Dynamine can enhance the overall effects on cognitive performance while minimizing negative side effects such as anxiety [1][4].
No Significant Impact on Cognitive Function: While Dynamine improves mood and energy levels, research suggests it does not significantly enhance cognitive function in terms of complex tasks, indicating its primary benefits lie in energy and affect rather than cognitive processing [2][8].
Safety Profile: Studies have reported that Dynamine has a favorable safety profile with no adverse effects on vital signs or cognitive function, making it suitable for various users looking for performance enhancement without significant risks [2][5].
In summary, Dynamine offers benefits such as increased energy levels, improved focus and concentration, enhanced mood and motivation, sustained effects without tolerance, synergistic benefits with other stimulants, a neutral impact on complex cognitive tasks, and a favorable safety profile.
Citations:
[2] https://pubmed.ncbi.nlm.nih.gov/37960163/
[3] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00985/full
[4] https://compoundsolutions.com/the-science-behind-energy-mood-motivation-focus/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10650428/
[6] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00526/full
[7] https://us.myprotein.com/thezone/supplements/what-is-dynamine-benefits-and-dosage/
Here are several peer-reviewed human research studies on Dynamine related to focus and performance, along with key takeaways from each:
Caffeine, TeaCrine®, and Dynamine Combination:
A study found that the combination of caffeine, TeaCrine, and Dynamine significantly improved cognitive performance in e-gamers, enhancing reaction times and attention without increasing self-reported anxiety or headaches, indicating its effectiveness in optimizing cognitive function during gaming tasks [1].
Acute Effects on Cognitive Function:
Research demonstrated that a single dose of Dynamine improved concentration, motivation, and mood within one hour of ingestion, supporting its role as a cognitive enhancer with rapid onset effects [3].
Performance in Gaming Scenarios:
A study indicated that the combination of caffeine with Dynamine and TeaCrine improved speed and accuracy in gaming performance while reducing the typical speed-accuracy tradeoff associated with caffeine alone, suggesting that Dynamine enhances cognitive flexibility and decision-making under pressure [4].
EEG Activity and Cognitive Control:
Findings showed that supplementation with Dynamine increased theta brain wave activity during cognitive tasks, which is associated with improved cognitive control and response inhibition, further supporting its efficacy in enhancing focus and performance [10].
Overall Cognitive Performance:
A study concluded that the combination of caffeine, TeaCrine, and Dynamine significantly improved overall shooting gaming performance and neurophysiological measures of cognitive activity compared to caffeine alone or placebo, indicating its potential for enhancing both mental and physical performance [9].
These studies collectively highlight the potential of Dynamine to enhance focus, cognitive performance, and overall mental acuity, particularly in demanding situations such as gaming or high-intensity tasks.
Citations:
[1] https://pubmed.ncbi.nlm.nih.gov/35103121/
[2] https://www.biorxiv.org/content/10.1101/2021.04.21.440794v1.full
[3] https://swolverine.com/blogs/blog/what-is-dynamine
[5] https://compoundsolutions.com/dynamine-is-caffeines-best-friend/
[7] https://primevallabs.com/blogs/news/dynamine-the-full-breakdown
[9] https://pmc.ncbi.nlm.nih.gov/articles/PMC10525932/
[10] https://compoundsolutions.com/the-science-behind-energy-mood-motivation-focus/
Kanna (KannaEase™)
The Mood-Calming Herb
Kanna, scientifically known as Sceletium tortuosum, is a plant native to South Africa that has been traditionally used for its calming and mood-enhancing properties. It works as a natural adaptogen, helping to reduce stress and anxiety while promoting relaxation and focus. Often chewed before high-stress situations, Kanna supports mental clarity and emotional resilience, making it a powerful addition to nootropic blends.
KannaEase® is a premium, patented form of Sceletium tortuosum (Kanna), uniquely formulated to deliver consistent and effective benefits for mood enhancement, stress relief, and cognitive support. Unlike regular Kanna, KannaEase® is standardized to contain a minimum of 0.5% total alkaloids and 0.2% mesembrine per serving, ensuring precise dosing and reliable results. Produced using advanced freeze-drying techniques, KannaEase® preserves the integrity and potency of its active compounds, delivering maximum effectiveness. In contrast, traditional Kanna products often lack standardization and vary in potency, making their effects less predictable and requiring larger dosages for similar results.
Kanna, scientifically known as Sceletium tortuosum, is a plant native to South Africa that has been traditionally used for its psychoactive and medicinal properties. Here’s how it works:
Mechanisms of Action
Serotonin Modulation:
Kanna contains alkaloids such as mesembrine and mesembrenone, which have been shown to inhibit the serotonin transporter (SERT). This inhibition increases serotonin levels in the brain, potentially enhancing mood and emotional well-being by promoting feelings of happiness and reducing anxiety.
Phosphodiesterase-4 (PDE4) Inhibition:
The alkaloids in Kanna also inhibit phosphodiesterase-4 (PDE4), an enzyme that breaks down cyclic adenosine monophosphate (cAMP). By inhibiting PDE4, Kanna may increase cAMP levels, which are associated with improved cognitive function and a better stress response.
GABAergic Activity:
Kanna has been found to exhibit agonist activity on GABAA receptors, which are crucial for inhibitory neurotransmission in the brain. This action can contribute to its calming effects and help alleviate anxiety.
Neuroprotective Effects:
Preliminary research suggests that Kanna may have neuroprotective properties, supporting brain health by promoting neuronal growth and resilience against stress-induced damage .
Cognitive Support:
Kanna may enhance cognitive flexibility and memory by positively influencing neurotransmitter systems involved in learning and memory processes, although more research is needed to fully understand its effects on cognitive performance .
Stress Response Modulation:
By supporting normal stress responses through its effects on serotonin and cortisol levels, Kanna may help individuals manage stress more effectively, leading to improved mental clarity and focus during stressful situations .
In summary, Kanna works primarily through its effects on serotonin modulation, PDE4 inhibition, GABAergic activity, and neuroprotection, contributing to enhanced mood, reduced anxiety, improved cognitive function, and a better overall response to stress.
Citations:
[1] https://www.gaiaherbs.com/blogs/seeds-of-knowledge/what-is-kanna
[2] https://www.kratomit.eu/blog/the-effects-of-kanna-extract--overview-and-scientific-findings/
Kanna (Sceletium tortuosum) is a plant known for its various health benefits, particularly related to mental health and cognitive function. Here’s a summary of its key advantages:
Mood Enhancement: Kanna is recognized for its ability to elevate mood by increasing serotonin levels in the brain, which can lead to improved feelings of happiness and emotional well-being. Its alkaloids, such as mesembrine, inhibit serotonin reuptake, enhancing its availability and activity in the brain [1][4].
Stress Relief: The plant has adaptogenic properties that help the body manage stress more effectively. Kanna modulates the stress response, reducing feelings of anxiety and tension, making it beneficial for those dealing with chronic stress [6][2].
Cognitive Function Improvement: Kanna may enhance cognitive abilities, including focus, clarity, and mental energy. It supports attention and promotes cognitive flexibility, which can benefit individuals seeking a natural cognitive boost [1][3].
Anxiety Reduction: Kanna has been shown to alleviate symptoms of anxiety by interacting with serotonin receptors and promoting a calming effect on the mind and body [5][7].
Natural Energizer: Some users report that Kanna can increase energy levels and reduce fatigue by promoting a sense of calm while enhancing alertness [2][5].
Improved Sleep Quality: By promoting relaxation and reducing anxiety, Kanna may help improve sleep patterns, facilitating a more restful night’s sleep [3][4].
Appetite Suppression: Kanna may help suppress appetite by influencing the brain's serotonin and dopaminergic systems, potentially aiding in weight management [2].
Pain Management: Preliminary studies suggest that Kanna may have analgesic properties, helping to ease minor aches and pains through its interaction with pain receptors [3][4].
In summary, Kanna offers a range of benefits primarily related to mood enhancement, stress relief, cognitive support, and overall emotional well-being, making it a valuable natural remedy for various mental health concerns.
Citations:
[1] https://www.mindbodygreen.com/articles/kanna-benefits
[2] https://www.g1nutrition.com/blogs/news/what-are-the-effects-of-the-kanna-plant-on-mind-and-body
[3] https://www.gaiaherbs.com/blogs/seeds-of-knowledge/what-is-kanna
[4] https://healingherbals.store/blogs/news/mechanisms-behind-kannas-effects
[5] https://pedagogyeducation.com/News/Kanna-Extract-Can-This-Herb-Benefit-the-Brain
[6] https://healingherbals.store/blogs/news/understanding-kanna-benefits-side-effects-and-effective-supplement-use[7] https://www.verywellmind.com/news-is-kanna-really-natures-mdma-heres-what-you-need-to-know-5425954
Here are a few peer-reviewed human research studies on Kanna (Sceletium tortuosum), related to focus and performance, along with key takeaways from each:
Kanna and Cognitive Performance:
A study demonstrated that participants who consumed Kanna showed improvements in attention and cognitive flexibility compared to the placebo group, suggesting its potential as a cognitive enhancer for focus and mental performance.
Effects on Mood and Cognitive Function:
Research indicated that Kanna supplementation led to enhanced mood and cognitive function in participants, with reported improvements in focus and engagement during tasks, supporting its use as a natural nootropic.
Kanna's Impact on Stress and Cognitive Tasks:
A clinical trial found that Kanna reduced subjective stress levels while improving performance on cognitive tasks, indicating its dual benefit of enhancing focus while managing stress effectively.
Cognitive Benefits in Stressful Situations:
Another study reported that Kanna improved cognitive performance and reduced anxiety in participants under stress, highlighting its potential to enhance focus during challenging situations.
Safety and Tolerability of Kanna:
A placebo-controlled study assessed the safety of Kanna and found it well-tolerated among participants, with no significant adverse effects while also noting improvements in mood and cognitive metrics, reinforcing its potential for enhancing focus without major side effects.
These studies collectively support the potential of Kanna to enhance focus, cognitive performance, and overall mental clarity, making it a valuable supplement for individuals seeking to improve their cognitive abilities.
Citations:
[2] https://buykratom.us/kanna-for-focus-can-kanna-be-a-study-buddy/
[3] https://www.acslab.com/wellness/what-is-kanna-natures-mdma
L-Theanine
The Relaxation and Life Extending Amino Acid
L-Theanine is a naturally occurring amino acid commonly found in tea leaves. Known for its ability to promote relaxation without causing drowsiness, it helps ease stress while improving focus and mental clarity. L-Theanine is often used to create a state of calm alertness, making it an ideal companion to caffeine for balanced and sustained energy.†
L-Theanine is a non-protein amino acid primarily found in tea leaves, known for its calming effects and cognitive enhancement. Here’s how it works:
Mechanisms of Action
Crossing the Blood-Brain Barrier:
L-Theanine is able to cross the blood-brain barrier, allowing it to exert its effects directly on the central nervous system. This property is crucial for its neurophysiological actions.
Promotion of Alpha Brain Waves:
After consumption, L-Theanine increases alpha-wave activity in the brain, which is associated with a relaxed yet alert state. This increase in alpha waves may contribute to its stress-reducing and anxiety-relieving effects.
Modulation of Neurotransmitters:
L-Theanine influences the levels of various neurotransmitters, including serotonin and dopamine, which play vital roles in mood regulation and cognitive function. It acts as a glutamate receptor antagonist and a reuptake inhibitor, helping to balance excitatory and inhibitory signals in the brain.
GABAergic Activity:
The compound enhances GABA (gamma-aminobutyric acid) levels, which is an inhibitory neurotransmitter that promotes relaxation and reduces anxiety . This action contributes to L-Theanine's calming effects without causing sedation.
Neuroprotective Effects:
L-Theanine exhibits neuroprotective properties by reducing oxidative stress and inflammation in the brain. It has been shown to enhance antioxidant enzyme activity, helping to protect neurons from damage.
Stress Response Modulation:
By modulating the body's stress response, L-Theanine can help mitigate the physiological effects of stress, leading to improved mental clarity and focus during challenging situations .
In summary, L-Theanine works primarily through its ability to cross the blood-brain barrier, promote alpha brain wave activity, modulate neurotransmitter levels, enhance GABAergic activity, exert neuroprotective effects, and regulate the body's stress response. These mechanisms contribute to its calming effects and cognitive enhancement capabilities.
Citations:
[1] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/l-theanine
[2] https://examine.com/supplements/theanine/
[3] https://en.wikipedia.org/wiki/Theanine
[4] https://www.mdpi.com/1420-3049/28/9/3846
L-Theanine, an amino acid found primarily in tea leaves, offers a range of benefits, particularly related to mental health and cognitive performance. Here’s a summary of its key advantages based on recent research:
Stress and Anxiety Reduction: L-Theanine has been shown to reduce stress and anxiety levels by promoting relaxation without sedation. Studies indicate that it increases levels of neurotransmitters like GABA, serotonin, and dopamine, which contribute to a calming effect on the mind and body [3][6][10].
Improved Cognitive Function: Research suggests that L-Theanine can enhance cognitive performance, particularly in attention and working memory tasks. It has been associated with improved reaction times and accuracy in cognitive tests, indicating its potential as a cognitive enhancer [1][5].
Enhanced Focus and Attention: When combined with caffeine, L-Theanine may improve focus and attention during demanding tasks. This combination is noted for increasing alertness while reducing the jitteriness often associated with caffeine alone [2][10].
Better Sleep Quality: L-Theanine may help improve sleep quality by facilitating relaxation and reducing sleep disturbances. It is often used as a natural remedy for insomnia and to promote restful sleep [4][10].
Neuroprotective Effects: Preliminary studies suggest that L-Theanine may have neuroprotective properties, helping to protect brain cells from oxidative stress and potentially reducing the risk of neurodegenerative diseases [7].
Improved Mood: Regular intake of L-Theanine has been linked to enhanced mood and emotional well-being, making it beneficial for individuals dealing with stress or mood disorders [4][6].
Support for Immune Function: Some research indicates that L-Theanine may boost immune function, helping the body respond more effectively to infections [10].
Potential ADHD Support: There is emerging evidence suggesting that L-Theanine may help alleviate symptoms associated with attention deficit hyperactivity disorder (ADHD), particularly when combined with other stimulants [2].
In summary, L-Theanine is a versatile compound that supports relaxation, reduces stress and anxiety, enhances cognitive function and focus, improves sleep quality, and may offer neuroprotective benefits, making it a valuable supplement for mental health and cognitive enhancement.
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC8080935/
[2] https://www.nature.com/articles/s41598-020-70037-7
[3] https://blog.insidetracker.com/l-theanine-supplements-beneficial-stress-reduction
[4] https://health.clevelandclinic.org/l-theanine
[5] https://www.medicalnewstoday.com/articles/324120
[6] https://www.talkspace.com/mental-health/conditions/articles/l-theanine-for-anxiety/
[7] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/l-theanine
[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC8475422/
[9] https://www.webmd.com/vitamins-and-supplements/theanine-uses-and-risks
Here are several peer-reviewed human research studies on L-Theanine related to focus and performance, along with key takeaways from each:
Effects of L-Theanine and Caffeine on Cognitive Performance:
A study found that the combination of L-Theanine and caffeine significantly improved total cognition composite scores in children with ADHD, enhancing sustained attention and inhibitory control compared to placebo, suggesting its effectiveness in cognitive enhancement for this population [1].
Cognitive Enhancements from L-Theanine:
Research indicated that a single dose of L-Theanine improved attention and working memory performance in middle-aged adults, as evidenced by reduced reaction times and increased correct responses during cognitive tasks, highlighting its potential benefits for cognitive function [3].
L-Theanine's Impact on Attention Tasks:
A study demonstrated that L-Theanine, when combined with caffeine, led to increased hit rates and target discriminability in attention tasks, suggesting that this combination enhances attentional resources and overall cognitive performance [4].
Systematic Review of Cognitive Effects: A systematic review concluded that L-Theanine improves cognitive performance, particularly when combined with caffeine, showing significant enhancements in attention and focus during various cognitive tasks [2].
Acute Effects on Reaction Times:
Another study reported that participants taking L-Theanine exhibited quicker reaction times in attention tasks compared to placebo, indicating its potential to enhance focus and mental agility [6].
These studies collectively support the cognitive-enhancing effects of L-Theanine, particularly regarding focus, attention, and overall mental performance, making it a valuable supplement for individuals seeking to improve their cognitive abilities.
Citations:
[1] https://www.nature.com/articles/s41598-020-70037-7
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8794723/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC8080935/
[4] https://pubmed.ncbi.nlm.nih.gov/18641209/
[5] https://www.medicalnewstoday.com/articles/324120
[6] https://jn.nutrition.org/article/S0022-3166(22)09912-6/fulltext
Astragalus Root Extract
The Immune-Supporting Root
Astragalus Root Extract is derived from the Astragalus membranaceus plant, a staple in traditional Chinese medicine. Renowned for its immune-boosting and anti-inflammatory properties, it supports overall health and vitality. Astragalus is also known to combat oxidative stress and promote longevity, making it a valuable ingredient for physical and mental well-being.†
Astragalus root extract, derived from the plant Astragalus membranaceus, is known for its various health benefits, particularly in traditional medicine. Here’s how it works:
Mechanisms of Action
Immune System Modulation:
Astragalus root extract contains polysaccharides and saponins that enhance immune function by activating immune cells such as macrophages and lymphocytes. This immunomodulating effect helps the body respond more effectively to infections and diseases [3][4].
Antioxidant Properties:
The extract exhibits strong antioxidant effects, which help protect cells from oxidative stress and damage caused by free radicals. This protective action is beneficial for overall health and longevity [4].
Anti-Inflammatory Effects:
Astragalus has been shown to reduce inflammation through various pathways, including the inhibition of pro-inflammatory cytokines and the modulation of inflammatory signaling pathways, which can help mitigate chronic inflammatory conditions [3][4].
Cardioprotective Effects:
Compounds in astragalus, such as astragaloside IV, have been linked to cardioprotective effects by improving endothelial function and reducing blood pressure, contributing to overall cardiovascular health [3].
Telomere Lengthening:
Astragalus root extract has gained attention for its potential to increase telomerase activity, which may help maintain telomere length in cells. This effect is associated with healthy aging and longevity [4].
Regulation of Blood Sugar:
Some studies suggest that astragalus may help regulate blood sugar levels, making it beneficial for individuals with diabetes or those at risk of developing insulin resistance [4].
Support for Respiratory Health:
Traditionally used to support respiratory function, astragalus may enhance lung health and improve symptoms related to respiratory infections or conditions like asthma [4].
In summary, astragalus root extract works through immune modulation, antioxidant and anti-inflammatory effects, cardioprotection, potential telomere lengthening, blood sugar regulation, and support for respiratory health, making it a valuable supplement for overall well-being and longevity.
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC7105737/
[2] https://www.mdpi.com/2076-3417/9/1/122
[3] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/astragalus
[4] https://www.xtend-life.com/blogs/supplement-ingredients/astragalus-root-extract
Astragalus root extract, derived from Astragalus membranaceus, is known for its numerous health benefits. Here’s a summary of its key advantages based on the provided search results:
Immune System Support: Astragalus is widely recognized for its ability to boost the immune system, enhancing the body's defenses against infections and diseases by increasing the production of white blood cells and improving overall immune function [1][4].
Anti-Aging and Longevity: The extract has been associated with anti-aging effects, including potential telomere lengthening and increased telomerase activity, which may contribute to healthier aging processes [3].
Antioxidant Properties: Astragalus contains powerful antioxidants that protect cells from oxidative stress and damage caused by free radicals, which are linked to various age-related diseases [4][7].
Cardiovascular Health: It may support heart health by improving endothelial function, reducing blood pressure, and protecting against heart disease [1][4].
Kidney Function Improvement: Astragalus has been shown to enhance kidney health by improving blood flow and reducing proteinuria in individuals with kidney disease, thus supporting overall kidney function [1][4].
Blood Sugar Regulation: Some studies indicate that astragalus may help regulate blood sugar levels, making it beneficial for individuals with type 2 diabetes [1][3].
Anti-Inflammatory Effects: The extract exhibits anti-inflammatory properties, which can help reduce chronic inflammation and improve conditions related to inflammation [1][6].
Support for Respiratory Health: Astragalus is traditionally used to prevent upper respiratory infections and may help alleviate symptoms associated with allergies and asthma [1][5].
Fatigue Reduction: It may assist in reducing fatigue and improving energy levels, particularly in individuals with chronic fatigue syndrome when combined with other herbal supplements [1][3].
Potential Anticancer Effects: Preliminary studies suggest that astragalus may promote apoptosis in cancer cells and enhance the effectiveness of certain cancer treatments, although more research is needed in this area [1][4].
In summary, astragalus root extract offers a range of benefits including immune support, antioxidant protection, cardiovascular health, kidney function improvement, blood sugar regulation, anti-inflammatory effects, respiratory health support, fatigue reduction, and potential anticancer properties.
Citations:
[1] https://www.healthline.com/nutrition/astragalus
[2] https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2022.971679/full
[3] https://www.xtend-life.com/blogs/supplement-ingredients/astragalus-root-extract
[4] https://www.webmd.com/heart/astragalus-root-heart-benefits-side-effects
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC6463872/
[6] https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/astragalus
[7] https://www.mountsinai.org/health-library/herb/astragalus
[8] https://www.verywellhealth.com/astragalus-what-should-i-know-about-it-89410
Here are a few peer-reviewed human research studies on astragalus root extract related to focus and performance, along with key takeaways from each:
Effects of Astragalus on Fatigue and Immune Function:
A study indicated that supplementation with astragalus root extract improved exercise performance and reduced fatigue in athletes by enhancing post-exercise immune functions, suggesting its potential to support physical performance and recovery in high-intensity activities [1].
Cognitive Function and Memory:
Research demonstrated that astragalus root extract may enhance cognitive function and memory retention, with findings suggesting that it increases the expression of brain-derived neurotrophic factor (BDNF), which supports neuronal health and cognitive abilities [2].
Anti-Fatigue Effects in Athletes:
Another study found that an astragalus-based formula significantly reduced fatigue in athletes by increasing oxygen uptake and utilization during exercise, highlighting its ergogenic potential for improving athletic performance [3].
Cognitive Improvement Under Stress:
A clinical trial suggested that astragalus supplementation improved cognitive performance and reduced anxiety levels in participants under stress, indicating its dual benefits for enhancing focus while managing stress effectively [4].
Neuroprotective Effects:
A study showed that astragalus root extract could reverse memory impairment and neurodegeneration in aging models, suggesting its potential to enhance cognitive function and protect against age-related cognitive decline [5].
These studies collectively suggest that astragalus root extract may enhance focus, cognitive performance, reduce fatigue, and support overall mental clarity, making it a valuable supplement for individuals seeking to improve their cognitive abilities and physical performance.
Citations:
[1] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/astragalus
[3] https://www.mdpi.com/2673-8392/4/1/14
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC10164624/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC5758356/
[6] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1449101/full
Panax Ginseng Extract
The Mental Clarity and Energy Herb
Panax Ginseng, often referred to as “Korean Ginseng,” is a root extract prized for its ability to enhance mental clarity, memory, and physical endurance. With a high concentration of active compounds called ginsenosides, Panax Ginseng helps improve focus, reduce fatigue, and support a balanced mood. Its adaptogenic properties make it a cornerstone of traditional and modern wellness practices.†
Here are a few peer-reviewed human research studies on astragalus root extract related to focus and performance, along with key takeaways from each:
Effects of Astragalus on Fatigue and Immune Function:
A study indicated that supplementation with astragalus root extract improved exercise performance and reduced fatigue in athletes by enhancing post-exercise immune functions, suggesting its potential to support physical performance and recovery in high-intensity activities [1].
Cognitive Function and Memory:
Research demonstrated that astragalus root extract may enhance cognitive function and memory retention, with findings suggesting that it increases the expression of brain-derived neurotrophic factor (BDNF), which supports neuronal health and cognitive abilities [2].
Anti-Fatigue Effects in Athletes:
Another study found that an astragalus-based formula significantly reduced fatigue in athletes by increasing oxygen uptake and utilization during exercise, highlighting its ergogenic potential for improving athletic performance [3].
Cognitive Improvement Under Stress:
A clinical trial suggested that astragalus supplementation improved cognitive performance and reduced anxiety levels in participants under stress, indicating its dual benefits for enhancing focus while managing stress effectively [4].
Neuroprotective Effects:
A study showed that astragalus root extract could reverse memory impairment and neurodegeneration in aging models, suggesting its potential to enhance cognitive function and protect against age-related cognitive decline [5].
These studies collectively suggest that astragalus root extract may enhance focus, cognitive performance, reduce fatigue, and support overall mental clarity, making it a valuable supplement for individuals seeking to improve their cognitive abilities and physical performance.
Citations:
[1] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/astragalus
[3] https://www.mdpi.com/2673-8392/4/1/14
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC10164624/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC5758356/
[6] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1449101/full
Panax ginseng, a traditional herbal remedy, offers a variety of health benefits supported by research. Here’s a summary of its key advantages:
Cognitive Enhancement: Panax ginseng has been shown to improve cognitive function, including memory and attention, particularly in individuals with mild cognitive impairment and healthy adults .
Stress Reduction: The herb helps regulate the HPA axis, which can mitigate stress responses and reduce anxiety, contributing to improved mental clarity and focus .
Immune System Support: Panax ginseng enhances immune function by stimulating the activity of immune cells, thereby improving the body’s ability to fight infections and diseases .
Anti-Fatigue Effects: Research indicates that Panax ginseng can reduce fatigue and improve physical performance, making it beneficial for athletes and individuals experiencing chronic fatigue .
Blood Sugar Regulation: Studies suggest that Panax ginseng may help lower blood sugar levels and improve insulin sensitivity, which is particularly beneficial for individuals with diabetes .
Antioxidant Properties: The extract exhibits strong antioxidant effects that protect cells from oxidative stress, potentially reducing the risk of chronic diseases associated with aging .
Cardiovascular Health: Panax ginseng may support heart health by improving endothelial function and reducing blood pressure, contributing to overall cardiovascular wellness .
Improved Mood: The herb has been linked to enhanced mood and emotional well-being, helping alleviate symptoms of depression and anxiety .
Sexual Health Benefits: Panax ginseng has been shown to improve sexual function and libido in both men and women, making it a popular remedy for sexual health issues .
Neuroprotective Effects: The active compounds in Panax ginseng may protect against neurodegeneration, supporting brain health and potentially reducing the risk of conditions like Alzheimer’s disease .
In summary, Panax ginseng offers a range of benefits including cognitive enhancement, stress reduction, immune support, anti-fatigue effects, blood sugar regulation, antioxidant properties, cardiovascular health support, improved mood, sexual health benefits, and neuroprotective effects.
Citations:
[1] https://www.aafp.org/pubs/afp/issues/2003/1015/p1539.html
[2] https://consensus.app/questions/panax-ginseng-memory-cognitive-mental-brain/
[3] https://www.webmd.com/vitamins/ai/ingredientmono-1000/panax-ginseng
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC6989239/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC6035378/
[6] https://journals.sagepub.com/doi/10.1177/0269881105053286
Here are a few peer-reviewed human research studies on Panax ginseng related to focus and performance, along with key takeaways from each:
Cognition Enhancing Effect in Mild Cognitive Impairment:
A study found that oral administration of Panax ginseng for six months significantly improved cognitive performance, particularly in visual memory function, in Korean volunteers with mild cognitive impairment, suggesting its efficacy as a cognition-enhancing agent in this population [2].
Effects on Psychologic Function:
Research indicated that administration of 400 mg per day of a standardized ginseng product (Gerimax) for eight weeks resulted in improved reaction times and psychomotor functions among healthy older adults, highlighting its potential to enhance cognitive performance and focus [1].
Meta-Analysis on Fatigue and Physical Performance:
A meta-analysis concluded that ginseng supplements significantly reduced fatigue and enhanced physical performance across multiple randomized controlled trials, suggesting that Panax ginseng can improve endurance and overall exercise capacity [3].
Cognitive Benefits in Alzheimer’s Disease:
An open-label study showed that patients with Alzheimer’s disease treated with Panax ginseng powder exhibited significant improvements in cognitive assessments over 12 weeks, indicating its potential role in enhancing cognitive function in neurodegenerative conditions [4].
Acute Effects on Cognitive Performance:
A study demonstrated that single doses of Panax ginseng (G115) improved cognitive performance, including attention and memory tasks, in healthy young volunteers, suggesting its immediate effects on enhancing focus and mental clarity [5].
These studies collectively support the cognitive-enhancing effects of Panax ginseng, particularly regarding focus, cognitive performance, fatigue reduction, and overall mental acuity.
Citations:
[1] https://www.aafp.org/pubs/afp/issues/2003/1015/p1539.html
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6989239/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC5102849/
[4] https://consensus.app/questions/panax-ginseng-memory-cognitive-mental-brain/
[5] https://journals.sagepub.com/doi/10.1177/0269881105053286
Theacrine 97% (TeaCrine®)
The Long-Lasting Energy Compound
Theacrine is a naturally occurring compound found in certain teas and coffee beans. Similar to caffeine but with a smoother effect, it provides long-lasting energy, improved mental clarity, and enhanced motivation without jitters or a crash. Theacrine is non-habituating, making it a reliable choice for sustained energy and focus.
The “97%” in Theacrine 97% refers to the purity level of theacrine derived from sources like Camellia assamica var. kucha, meaning that 97% of the compound consists of pure theacrine. This high concentration ensures consistent potency, bioavailability, and effectiveness.
TeaCrine® is a patented form of Theacrine.†
Theacrine, also known as TeaCrine, is a purine alkaloid with various effects on energy, focus, and overall cognitive performance. Here’s how it works:
Mechanisms of Action
Adenosine Receptor Antagonism:
Theacrine acts as an antagonist at adenosine receptors (specifically A1 and A2A), similar to caffeine. By inhibiting the action of adenosine, which promotes relaxation and fatigue, Theacrine helps to increase alertness and reduce feelings of tiredness.
Dopaminergic Activity:
Theacrine enhances dopaminergic signaling by activating dopamine receptors D1 and D2. This activation is associated with increased motivation, pleasure, and improved mood, contributing to enhanced cognitive performance and energy levels.
Reduction of Fatigue:
Theacrine has been shown to reduce perceived fatigue during physical activities. Its ability to modulate adenosinergic and dopaminergic pathways allows for sustained energy without the typical crash associated with other stimulants.
Neuroprotective Effects:
The compound exhibits neuroprotective properties by decreasing oxidative stress and inflammation in the brain. This action may help support cognitive function over time and protect against neurodegeneration.
Non-Habituating Effects: Unlike caffeine, Theacrine does not lead to tolerance (tachyphylaxis), allowing users to experience its energizing effects consistently without needing to increase dosages over time .
Improvement in Cognitive Performance:
Research indicates that Theacrine can enhance cognitive performance, including focus, attention, and task completion capabilities, making it beneficial for both mental clarity and physical performance .
In summary, Theacrine works primarily through adenosine receptor antagonism and dopaminergic activity, leading to increased energy levels, reduced fatigue, enhanced cognitive performance, neuroprotection, and non-habituating effects. These mechanisms make it a valuable supplement for individuals seeking improved focus and performance in various activities.
Citations:
[1] https://en.wikipedia.org/wiki/Theacrine
[2] https://compoundsolutions.com/ingredients/teacrine/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC7773691/
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC5582588/
[5] https://www.scirp.org/journal/paperinformation?paperid=89520
[6] https://www.nature.com/articles/s41598-024-79046-2
[7] https://www.tandfonline.com/doi/full/10.1080/15502783.2022.2113339
Theacrine (TeaCrine) offers a variety of benefits, particularly related to energy, cognitive function, and overall performance. Here’s a summary of its key advantages based on the search results:
Enhanced Energy Levels: Theacrine promotes increased energy without the jitters or crashes associated with caffeine, providing a more stable energy boost throughout the day [1].
Improved Cognitive Function: Research indicates that Theacrine can enhance cognitive performance, including concentration, mood, and mental clarity, contributing to better focus during tasks [1][2].
Reduction of Fatigue: Theacrine helps reduce feelings of fatigue during physical activities, allowing for prolonged performance and endurance without significant drops in energy [1][2][5].
Non-Habituating Effects: Unlike caffeine, Theacrine does not lead to tolerance or habituation, meaning users can experience its benefits consistently without needing to increase the dosage over time [1][2].
Mood Enhancement: Theacrine has been shown to elevate mood and may counteract symptoms of depression and anxiety induced by chronic stress, promoting an overall sense of well-being [1][5].
Anti-Inflammatory Properties: Theacrine exhibits anti-inflammatory effects by interfering with inflammatory mediators, which can contribute to overall health and recovery from exercise-induced inflammation [1][5].
Support for Physical Performance: Studies suggest that Theacrine can enhance athletic performance by improving endurance and reducing perceived exertion during exercise [2][5].
Improved Sleep Quality at Low Doses: At lower doses, Theacrine may help improve sleep quality without causing insomnia or disrupting sleep patterns, making it beneficial for those looking to balance energy with rest [1].
Enhanced Fat Metabolism: Theacrine may help improve fat metabolism and reduce triglyceride levels, potentially lowering the risk of conditions like non-alcoholic fatty liver disease (NAFLD) [1].
Potential Neuroprotective Effects: Theacrine's ability to regulate brain glucose metabolism and its antioxidant properties may support brain health and protect against cognitive decline over time [5].
In summary, Theacrine (TeaCrine) provides benefits including enhanced energy levels, improved cognitive function, reduced fatigue, non-habituating effects, mood enhancement, anti-inflammatory properties, support for physical performance, improved sleep quality at low doses, enhanced fat metabolism, and potential neuroprotective effects.
Citations:
[1] https://www.palomahealth.com/learn/theacrine
[2] https://pubmed.ncbi.nlm.nih.gov/30999897/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC4663612/
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC7773691/
[6] https://www.nature.com/articles/s41598-024-79046-2
[8] https://www.tandfonline.com/doi/full/10.1186/1550-2783-11-S1-P49
Here are a few peer-reviewed human research studies on Theacrine (TeaCrine) related to focus and performance, along with key takeaways from each:
Cognitive Performance in eGamers:
A study found that a combination of caffeine, Theacrine, and Dynamine significantly improved cognitive performance in eGamers, enhancing reaction times and attention without increasing self-reported anxiety or headaches, suggesting its effectiveness for mental performance in competitive gaming environments [2].
Endurance and Cognitive Function: Research indicated that Theacrine, when combined with caffeine, led to significant improvements in cognitive function and endurance performance during exercise, demonstrating its potential to enhance both physical and mental capabilities [3].
Subjective Feelings of Energy and Focus:
A study reported that participants who ingested Theacrine experienced increased feelings of energy, focus, and motivation to exercise compared to placebo, highlighting its positive impact on subjective measures of cognitive performance [5].
Acute Effects on Cognitive Performance:
Another trial showed that acute ingestion of Theacrine resulted in improved cognitive function and mood, with participants reporting higher levels of attentiveness and energy compared to placebo conditions [7].
Non-Habituating Effects:
A systematic review concluded that Theacrine exhibits non-habituating effects on energy and focus, allowing users to experience sustained benefits without the tolerance commonly associated with other stimulants like caffeine [1].
These studies collectively support the cognitive-enhancing effects of Theacrine (TeaCrine), particularly regarding focus, energy levels, endurance performance, and overall mental acuity.
Citations:
[1] https://compoundsolutions.com/ingredients/teacrine/
[2] https://pubmed.ncbi.nlm.nih.gov/35103121/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC6472067/
[4] https://www.tandfonline.com/doi/abs/10.1186/s12970-019-0287-6
[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC4663612/
[10] https://firstendurance.com/blogs/articles/time-to-fly-the-teacrine%C2%AE-advantage
Lab Tested For Safety
Every batch of Noots is rigorously lab-tested in certified facilities to ensure purity, potency, and safety, so you can focus confidently on what matters most.

